Amyloid pathology is associated with semantic loss in patients with subjective cognitive decline

Background Evidence is emerging that subtle language decline an early indicator of Alzheimer’s disease (AD). This study assessed change in semantic and letter fluency individuals with subjective cognitive (SCD), examined whether trajectories differed between without amyloid-beta (Aβ)-pathology. Method Longitudinal data from 437 the memory clinic-based Amsterdam Dementia Cohort were included (Age 61±8 years, 184(42%) Female, follow-up time 5.3±3.7 years; Table 1). Participants classified as SCD at baseline, had available baseline Aβ-information least 1 on or fluency. Baseline Aβ-status was dichotomized positive/negative based local cut-offs for Aβ1-42 concentrations cerebrospinal fluid, visual inspection amyloid positron emission tomography-imaging (Florbetapir PiB). Two linear mixed models (LMM) used to investigate Models time*Aβ-status predictors interest, a random intercept participant, age, sex, education adjusted for. LMMs subsequently stratified Aβ-status. Result At groups did not differ (p = 0.313) 0.294). Over Aβ-positive changed more rapidly compared Aβ-negative (β -0.32,CI -0.49 – -0.14;p<.001). The group declined 0.35 words per year (CI -0.20;p<.001), while show 0.03;CI -0.12 0.06;p 0.496) (Figure On differently -0.38;CI -0.72 -0.04;p 0.028), extent progress 0.10;CI -0.21 0.41;p 0.533), improved 0.47 0.29 0.65;p<.001) 2). Conclusion Our results indicate decreased fluency, but remained stable In contrast, they over time, which might suggest learning effect. These findings presence Aβ-pathology characterized by loss, highlighting potential performance biomarker SCD.